Product Data Sheet

FG-4592 (Roxadustat)

Catalog No. A11237

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FG-4592 is a novel hypoxia inducible factor prolyl hydroxylase inhibitor, in CKD anemia.
Adooq's FG-4592 (Roxadustat) has been cited by 5 publications
  • Weilin Song, .et al. , Biomedicines, 2022, Dec 23;11(1):37 PMID: 36672545
  • Singh C, .et al. , JCI Insight, 2019, Jul 25;4(14) PMID: 31341109
  • Hideaki Nakamura, .et al. , PLoS One, 2018, 13(2): e0192136 PMID: 29466367
  • Singh C, .et al. , Invest Ophthalmol Vis Sci, 2018, Jul 2;59(8):3440-3448 PMID: 30025089
  • George Hoppe, .et al. , Proc Natl Acad Sci U S A, 2016, May 3; 113(18): E2516-E2525 PMID: 27091985
    • Chemical Information
    Catalog Num A11237
    M. Wt 352.3
    Formula C19H16N2O5
    Purity >98%
    Storage at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base)
    CAS No. 808118-40-3
    Synonyms FG4592, ASP1517
    SMILES CC1=NC(=C(C2=C1C=C(C=C2)OC3=CC=CC=C3)O)C(=O)NCC(=O)O
    Storage

    Store lyophilized at -20ºC, keep desiccated.
    In lyophilized form, the chemical is stable for 36 months.
    In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.
    Biological Activity
    Discription FG-4592 is a novel hypoxia inducible factor prolyl hydroxylase inhibitor, in CKD anemia.
    Targets
    Target Value
    Solubility
    In vitro (25°C) DMSO 62 mg/mL (175.96 mM)
    Water Insoluble
    Ethanol Insoluble
    In vivo 5% DMSO+40% PEG 300+5% Tween 80+50% ddH2O 9 mg/mL
    * <1 mg/ml means slightly soluble or insoluble.
    * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
    Preparing Stock Solutions
    Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
    0.1 mM 28.38 mL 141.92 mL 283.85 mL
    0.5 mM 5.68 mL 28.38 mL 56.77 mL
    1 mM 2.84 mL 14.19 mL 28.38 mL
    5 mM 0.57 mL 2.84 mL 5.68 mL
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    SHIPPING AND STORAGE
    Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.