Product Data Sheet

PR-171 (Carfilzomib)

Catalog No. A11278

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PR-171 (Carfilzomib) is a tetrapeptide epoxyketone and a selective proteasome inhibitor. It is an analog of epoxomicin.
Adooq's PR-171 (Carfilzomib) has been cited by 6 publications
  • Andrew Thorne, .et al. , PLoS One, 2023, Jun 8;18(6):e0286783 PMID: 37289679
  • Mahmood Barani, .et al. , J Drug Deliv Sci Technol, 2023, 81: 104268
  • Ori Kalid, .et al. , Chem Biol Drug Des, 2022, Mar 24 PMID: 35322538
  • Abbas Rahdar, .et al. , Journal of Molecular Liquids, 2022, 346: 118271
  • Sadegh Zarei, .et al. , J Appl Biotechnol Rep, 2019, June;6(2):45-49
  • Fujita KI, .et al. , J Pharm Sci, 2017, Sep;106(9):2632-2641 PMID: 28479358
    • Chemical Information
    Catalog Num A11278
    M. Wt 719.9
    Formula C40H57N5O7
    Purity >98%
    Storage at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base)
    CAS No. 868540-17-4
    Synonyms PR-171-007
    SMILES CC(C)C[C@@H](C(=O)[C@]1(CO1)C)NC(=O)[C@H](CC2=CC=CC=C2)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCC3=CC=CC=C3)NC(=O)CN4CCOCC4
    Storage

    Store lyophilized at -20ºC, keep desiccated.
    In lyophilized form, the chemical is stable for 36 months.
    In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.
    Biological Activity
    Discription PR-171 (Carfilzomib) is a tetrapeptide epoxyketone and a selective proteasome inhibitor. It is an analog of epoxomicin.
    Targets
    Target Value
    Solubility
    In vitro (25°C) DMSO 46 mg/mL (63.89 mM)
    Water Insoluble
    Ethanol Insoluble
    In vivo 2% DMSO+30% PEG 300+2%Tween 80+ddH2O 1 mg/mL
    * <1 mg/ml means slightly soluble or insoluble.
    * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
    Preparing Stock Solutions
    Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
    0.1 mM 13.89 mL 69.45 mL 138.91 mL
    0.5 mM 2.78 mL 13.89 mL 27.78 mL
    1 mM 1.39 mL 6.95 mL 13.89 mL
    5 mM 0.28 mL 1.39 mL 2.78 mL
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    SHIPPING AND STORAGE
    Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.