Product Data Sheet

Bardoxolone methyl (RTA 402)

Catalog No. A11323

main product photo
Bardoxolone methyl is an orally-available first-in-class synthetic triterpenoid. It is an inducer of the Nrf2 pathway, which can suppress oxidative stress and inflammation.
Adooq's Bardoxolone methyl (RTA 402) has been cited by 4 publications
  • Nakamura S, .et al. , Invest Ophthalmol Vis Sci, 2019, 60: 1943-1952 PMID: 31050722
  • Hisamichi M, .et al. , Hypertens Res, 2018, Jan;41(1):8-17 PMID: 28978980
  • Takahiko Imai, .et al. , Neurobiol Dis, 2016, May;89:136-46 PMID: 26850917
  • Takagi T, .et al. , Free Radic Biol Med, 2014, 72:124-33 PMID: 24746614
    • Chemical Information
    Catalog Num A11323
    M. Wt 505.7
    Formula C32H43NO4
    Purity >98%
    Storage at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base)
    CAS No. 218600-53-4
    Synonyms NSC 713200, CDDO-methyl ester
    SMILES C[C@@]12CC[C@]3(CCC(C[C@H]3[C@H]1C(=O)C=C4[C@]2(CC[C@@H]5[C@@]4(C=C(C(=O)C5(C)C)C#N)C)C)(C)C)C(=O)OC
    Storage

    Store lyophilized at -20ºC, keep desiccated.
    In lyophilized form, the chemical is stable for 36 months.
    In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.
    Biological Activity
    Discription Bardoxolone methyl is an orally-available first-in-class synthetic triterpenoid. It is an inducer of the Nrf2 pathway, which can suppress oxidative stress and inflammation.
    Targets
    Target Value
    Solubility
    In vitro (25°C) DMSO 21 mg/mL (41.52 mM)
    Water Insoluble
    Ethanol Insoluble
    In vivo 4%DMSO+30% PEG300+5% Tween+61%ddH2O 2.3 mg/mL
    * <1 mg/ml means slightly soluble or insoluble.
    * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
    Preparing Stock Solutions
    Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
    0.1 mM 19.77 mL 98.87 mL 197.75 mL
    0.5 mM 3.95 mL 19.77 mL 39.55 mL
    1 mM 1.98 mL 9.89 mL 19.77 mL
    5 mM 0.4 mL 1.98 mL 3.95 mL
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    SHIPPING AND STORAGE
    Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.