Product Data Sheet

Dabrafenib (GSK2118436A)

Catalog No. A11381

main product photo
Dabrafenib is a potent and selective inhibitor of B-RAF protein kinase carrying V600E mutation, currently in clinical trial.
Adooq's Dabrafenib (GSK2118436A) has been cited by 7 publications
  • Ali Talebi, .et al. , J Exp Clin Cancer Res, 2023, Apr 19;42(1):92 PMID: 37072838
  • Yuki Shimizu, .et al. , Cancer Lett, 2022, Sep 1;543 PMID: 35724767
  • Aya Hasan Alshammari, .et al. , Biochem Pharmacol, 2022, Mar;197:114914 PMID: 35041812
  • Chenyang He, .et al. , Clinical and Translational Biophotonics, 2020, TTh3B.2
  • Hirosumi Tamura, .et al. , Oncol Rep, 2018, Aug; 40(2): 635-646 PMID: 29917168
  • Brittany M. Duggan, .et al. , Sci Rep, 2017, 7: 1578 PMID: 28484277
  • Fujita KI, .et al. , J Pharm Sci, 2017, Sep;106(9):2632-2641 PMID: 28479358
    • Chemical Information
    Catalog Num A11381
    M. Wt 519.6
    Formula C23H20F3N5O2S2
    Purity >98%
    Storage at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base)
    CAS No. 1195765-45-7
    Synonyms GSK2118436A
    SMILES CC(C)(C)C1=NC(=C(S1)C2=NC(=NC=C2)N)C3=C(C(=CC=C3)NS(=O)(=O)C4=C(C=CC=C4F)F)F
    Storage

    Store lyophilized at -20ºC, keep desiccated.
    In lyophilized form, the chemical is stable for 36 months.
    In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.
    Biological Activity
    Discription Dabrafenib is a potent and selective inhibitor of B-RAF protein kinase carrying V600E mutation, currently in clinical trial.
    Targets
    Target Value
    Solubility
    In vitro (25°C) DMSO 28 mg/mL (53.89 mM)
    Water Insoluble
    Ethanol Insoluble
    In vivo 2% DMSO+45% PEG 300+2% Tween 80+ddH2O 4 mg/mL
    * <1 mg/ml means slightly soluble or insoluble.
    * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
    Preparing Stock Solutions
    Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
    0.1 mM 19.25 mL 96.23 mL 192.46 mL
    0.5 mM 3.85 mL 19.25 mL 38.49 mL
    1 mM 1.92 mL 9.62 mL 19.25 mL
    5 mM 0.38 mL 1.92 mL 3.85 mL
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    SHIPPING AND STORAGE
    Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.