Product Data Sheet

PA-824 (Pretomanid)

Catalog No. A11401

main product photo
PA-824 is an experimental anti-tuberculosis drug.
Adooq's PA-824 (Pretomanid) has been cited by 4 publications
  • Vijaya Bharti, .et al. , Cell Rep, 2022, Dec 20;41(12):111826 PMID: 36543138
  • Thanh Quang Nguyen, .et al. , Antimicrob Agents Chemother, 2022, Dec 20;66(12):e0044822 PMID: 36321819
  • Wang X, .et al. , Cell Chem Biol, 2019, Nov 7. pii: S2451-9456(19)30355-1 PMID: 31711854
  • Alexandre López-Gavín, .et al. , Int J Antimicrob Agents., 2015, Nov;46(5):582-5 PMID: 26421981
    • Chemical Information
    Catalog Num A11401
    M. Wt 359.3
    Formula C14H12F3N3O5
    Purity >98%
    Storage at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base)
    CAS No. 187235-37-6
    Synonyms PA824
    SMILES C1[C@@H](COC2=NC(=CN21)[N+](=O)[O-])OCC3=CC=C(C=C3)OC(F)(F)F
    Storage

    Store lyophilized at -20ºC, keep desiccated.
    In lyophilized form, the chemical is stable for 36 months.
    In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.
    Biological Activity
    Discription PA-824 is an experimental anti-tuberculosis drug.
    Targets
    Target Value
    Solubility
    In vitro (25°C) DMSO 64 mg/mL (178.14 mM)
    Water Insoluble
    Ethanol 14 mg/mL (38.96 mM)
    In vivo 0.5% methylcellulose 28 mg/mL
    * <1 mg/ml means slightly soluble or insoluble.
    * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
    Preparing Stock Solutions
    Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
    0.1 mM 27.83 mL 139.16 mL 278.32 mL
    0.5 mM 5.57 mL 27.83 mL 55.66 mL
    1 mM 2.78 mL 13.92 mL 27.83 mL
    5 mM 0.56 mL 2.78 mL 5.57 mL
    RETURN POLICY
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    SHIPPING AND STORAGE
    Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.