Product Data Sheet

Ganetespib (STA-9090)

Catalog No. A11402

main product photo
Ganetespib is a potent, synthetic, small molecule inhibitor of Hsp90, a chaperone protein that is essential to the function of certain other proteins that drive the growth, proliferation, and survival of many different types of cancer.
Adooq's Ganetespib (STA-9090) has been cited by 7 publications
  • Dilay Karademir, .et al. , Med Oncol, 2023, Jul 11;40(8):234 PMID: 37432531
  • Tung-Yun Wu, .et al. , J Adv Res, 2022, Jun 22;S2090-1232(22)00148-5 PMID: 35752438
  • Aykut Ozgur, .et al. , J Chemother, 2021, Apr 2;1-10 PMID: 33794753
  • Michael Heider, .et al. , Mol Cell, 2021, Mar 18;81(6):1170-1186 PMID: 33571422
  • Kosinsky RL, .et al. , Cell Death Dis, 2019, Dec 4;10(12):911 PMID: 31801945
  • Yamada-Kanazawa S, .et al. , Br J Dermatol, 2017, Aug;177(2):456-469 PMID: 28078663
  • Hiroki Murano, .et al. , Plant Biotechnol Rep, 2017, 11:107-113
    • Chemical Information
    Catalog Num A11402
    M. Wt 364.4
    Formula C20H20N4O3
    Purity >98%
    Storage at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base)
    CAS No. 888216-25-9
    Synonyms STA9090
    SMILES CC(C)C1=CC(=C2NNC(=O)N2C3=CC4=C(C=C3)N(C=C4)C)C(=O)C=C1O
    Storage

    Store lyophilized at -20ºC, keep desiccated.
    In lyophilized form, the chemical is stable for 36 months.
    In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.
    Biological Activity
    Discription Ganetespib is a potent, synthetic, small molecule inhibitor of Hsp90, a chaperone protein that is essential to the function of certain other proteins that drive the growth, proliferation, and survival of many different types of cancer.
    Targets
    Target Value
    Solubility
    In vitro (25°C) DMSO 37 mg/mL (101.53 mM)
    Water Insoluble
    Ethanol Insoluble
    In vivo 5% DMSO+45% PEG 300+ddH2O 10 mg/mL
    * <1 mg/ml means slightly soluble or insoluble.
    * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
    Preparing Stock Solutions
    Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
    0.1 mM 27.44 mL 137.21 mL 274.42 mL
    0.5 mM 5.49 mL 27.44 mL 54.88 mL
    1 mM 2.74 mL 13.72 mL 27.44 mL
    5 mM 0.55 mL 2.74 mL 5.49 mL
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    SHIPPING AND STORAGE
    Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.