Product Data Sheet

Istradefylline (KW-6002)

Catalog No. A11451

main product photo
Istradefylline (KW-6002) is a selective antagonist at the A2A receptor. It has been found to be useful in the treatment of Parkinson's disease.
Adooq's Istradefylline (KW-6002) has been cited by 1 publications
  • PU Hamor, .et al. , Prog Neuropsychopharmacol Biol Psychiatry, 2020, Dec 20;103:109979 PMID: 32470496
  • Chemical Information
    Catalog NumA11451
    M. Wt384.4
    FormulaC20H24N4O4
    Purity>98%
    Storageat -20 °C 3 years (powder form); at -20 °C 6 months (Solution base)
    CAS No.155270-99-8
    SynonymsKW-6002,KW6002
    SMILESCCN1C2=C(C(=O)N(C1=O)CC)N(C(=N2)/C=C/C3=CC(=C(C=C3)OC)OC)C
    Biological Activity
    DescriptionIstradefylline (KW-6002) is a selective antagonist at the A2A receptor. It has been found to be useful in the treatment of Parkinson's disease.
    Targets
    TargetValue
    Solubility
    In vitro (25°C) DMSO5 mg/mL (13 mM)
    WaterInsoluble
    EthanolInsoluble
    In vivo 30% propylene glycol, 5% Tween 80, 65% D5W 28 mg/mL
    * <1 mg/ml means slightly soluble or insoluble.
    * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
    Preparing Stock Solutions
    Concentration / Solvent Volume / Mass1 mg5 mg10 mg
    0.1 mM26.01 mL130.07 mL260.15 mL
    0.5 mM5.2 mL26.01 mL52.03 mL
    1 mM2.6 mL13.01 mL26.01 mL
    5 mM0.52 mL2.6 mL5.2 mL
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    SHIPPING AND STORAGE
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