Product Data Sheet
Gliquidone
Catalog No. A11864
Gliquidone is an anti-diabetic agent that primarily targets pancreatic β-cells to enhance insulin secretion, thereby helping regulate blood glucose levels. It has demonstrated significant anti-inflammatory effects by reducing LPS-induced proinflammatory responses and inhibiting the phosphorylation of ERK, STAT3, and NF-κB in BV2 microglial cells. Additionally, Gliquidone effectively suppresses microgliosis and microglial hypertrophy while lowering levels of proinflammatory cytokines, such as COX-2 and IL-6, in murine models. Furthermore, Gliquidone exhibits anticancer activity against lung carcinoma cells and possesses antioxidant properties, making it valuable for research in type 2 diabetes and cancer.
Chemical Information
| Catalog Num | A11864 |
|---|---|
| M. Wt | 527.63 |
| Formula | C27H33N3O6S |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 33342-05-1 |
| Synonyms | AR-DF 26 |
| SMILES | O=S(C1=CC=C(CCN(C(C(C)(C)C2=C3C=C(OC)C=C2)=O)C3=O)C=C1)(NC(NC4CCCCC4)=O)=O |
Biological Activity
| Description | Gliquidone is an anti-diabetic agent that primarily targets pancreatic β-cells to enhance insulin secretion, thereby helping regulate blood glucose levels. It has demonstrated significant anti-inflammatory effects by reducing LPS-induced proinflammatory responses and inhibiting the phosphorylation of ERK, STAT3, and NF-κB in BV2 microglial cells. Additionally, Gliquidone effectively suppresses microgliosis and microglial hypertrophy while lowering levels of proinflammatory cytokines, such as COX-2 and IL-6, in murine models. Furthermore, Gliquidone exhibits anticancer activity against lung carcinoma cells and possesses antioxidant properties, making it valuable for research in type 2 diabetes and cancer. |
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RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
