Product Data Sheet
Neomycin sulfate
Catalog No. A11896
Neomycin sulfate is a phospholipase C inhibitor that modulates angiogenesis through its influence on calcium signaling pathways. This aminoglycoside antibiotic disrupts bacterial protein synthesis by binding irreversibly to the 30S ribosomal subunit. In addition to its antibacterial properties, neomycin sulfate effectively inhibits angiogenin-mediated nuclear translocation, cell proliferation, and angiogenesis. It also disrupts inositol trisphosphate (IP3)-mediated calcium release and electrical excitation-evoked calcium transients in skeletal muscle. Neomycin sulfate is utilized in cancer research and studies related to calcium signaling and angiogenesis.
Chemical Information
| Catalog Num | A11896 |
|---|---|
| M. Wt | 908.88 |
| Formula | C23H52N6O25S3 |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 1405-10-3 |
| Synonyms | Neomycin sulphate, Framycin sulfate |
| SMILES | O[C@H]1[C@H](O)[C@@H](N)[C@@H](O[C@@H]2[C@@H](N)C[C@@H](N)[C@H](O)[C@H]2O[C@@H]3O[C@H](CO)[C@@H](O[C@H]4O[C@@H](CN)[C@@H](O)[C@H](O)[C@H]4N)[C@H]3O)O[C@@H]1CN.[3H2SO4] |
Biological Activity
| Description | Neomycin sulfate is a phospholipase C inhibitor that modulates angiogenesis through its influence on calcium signaling pathways. This aminoglycoside antibiotic disrupts bacterial protein synthesis by binding irreversibly to the 30S ribosomal subunit. In addition to its antibacterial properties, neomycin sulfate effectively inhibits angiogenin-mediated nuclear translocation, cell proliferation, and angiogenesis. It also disrupts inositol trisphosphate (IP3)-mediated calcium release and electrical excitation-evoked calcium transients in skeletal muscle. Neomycin sulfate is utilized in cancer research and studies related to calcium signaling and angiogenesis. |
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RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
