Product Data Sheet

RITA (NSC 652287)

Catalog No. A11931

main product photo
RITA, also referred to as NSC 652287, is a trycyclic thiophene derivative that binds to MDM2, disrupting the MDM2-p53 complex and subsequently activating p53 and inducing apoptosis.
Adooq's RITA (NSC 652287) has been cited by 1 publications
  • M Kobayashi, .et al. , Oncotarget, 2020, May 5;11(18):1653-1665 PMID: 32405340
    • Chemical Information
    Catalog Num A11931
    M. Wt 292.4
    Formula C14H12O3S2
    Purity >98%
    Storage at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base)
    CAS No. 213261-59-7
    Synonyms NSC652287, p53 Activator III
    SMILES C1=C(SC(=C1)C2=CC=C(O2)C3=CC=C(S3)CO)CO
    Storage

    Store lyophilized at -20ºC, keep desiccated.
    In lyophilized form, the chemical is stable for 36 months.
    In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.
    Biological Activity
    Discription RITA, also referred to as NSC 652287, is a trycyclic thiophene derivative that binds to MDM2, disrupting the MDM2-p53 complex and subsequently activating p53 and inducing apoptosis.
    Targets
    Target Value
    Solubility
    In vitro (25°C) DMSO 56 mg/mL (191.53 mM)
    Water Insoluble
    Ethanol 8 mg/mL (27.36 mM)
    In vivo 30% propylene glycol, 5% Tween 80, 65% D5W 28 mg/mL
    * <1 mg/ml means slightly soluble or insoluble.
    * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
    Preparing Stock Solutions
    Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
    0.1 mM 34.2 mL 171 mL 342 mL
    0.5 mM 6.84 mL 34.2 mL 68.4 mL
    1 mM 3.42 mL 17.1 mL 34.2 mL
    5 mM 0.68 mL 3.42 mL 6.84 mL
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    SHIPPING AND STORAGE
    Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.