Product Data Sheet

(Z)-SMI-4a

Catalog No. A11945

main product photo
SIM-4a is a Pim kinase inhibitor that blocks mTORC1 activity via activation of AMPK. Mostly potent to Pim-2, does not significantly inhibit any other serine/threonine- or tyrosine-kinases.
Adooq's (Z)-SMI-4a has been cited by 1 publications
  • Liong S, .et al. , Placenta, 2017, May;53:101-112 PMID: 28487013
  • Chemical Information
    Catalog Num A11945
    M. Wt 273.2
    Formula C11H6F3NO2S
    Purity >98%
    Storage at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base)
    CAS No. 327033-36-3
    Synonyms SMI4a
    SMILES O=C(NC/1=O)SC1=C/C2=CC=CC(C(F)(F)F)=C2
    Storage

    Store lyophilized at -20ºC, keep desiccated.
    In lyophilized form, the chemical is stable for 36 months.
    In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

    Biological Activity
    Discription SIM-4a is a Pim kinase inhibitor that blocks mTORC1 activity via activation of AMPK. Mostly potent to Pim-2, does not significantly inhibit any other serine/threonine- or tyrosine-kinases.
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