Product Data Sheet

GW 4869

Catalog No. A11974

main product photo

GW4869 is a cell permeable, selective inhibitor of N-SMase (neutral sphingomyelinase).

Adooq's GW 4869 has been cited by 1 publications
  • Guohao Wang, .et al. , Nat Commun, 2021, Sep 30;12(1):5733 PMID: 34593794
  • Chemical Information
    Catalog Num A11974
    M. Wt 577.5
    Formula C30H28N6O2.2HCl
    Purity >98%
    Storage at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base)
    CAS No. 6823-69-4
    Synonyms GW-4869, GW4869
    SMILES C1NC(=NC1)C2=CC=C(C=C2)NC(=O)/C=C/C3=CC=C(C=C3)/C=C/C(=O)NC4=CC=C(C=C4)C5=NCCN5.O.Cl.Cl
    Storage

    Store lyophilized at -20ºC, keep desiccated.
    In lyophilized form, the chemical is stable for 36 months.
    In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

    Biological Activity
    Discription

    GW4869 is a cell permeable, selective inhibitor of N-SMase (neutral sphingomyelinase).

    Solubility
    In vitro DMSO Insoluble
    Water Insoluble
    Ethanol Insoluble
    * <1 mg/ml means slightly soluble or insoluble.
    * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
    Preparing Stock Solutions
    Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
    0.1 mM 17.32 mL 86.58 mL 173.16 mL
    0.5 mM 3.46 mL 17.32 mL 34.63 mL
    1 mM 1.73 mL 8.66 mL 17.32 mL
    5 mM 0.35 mL 1.73 mL 3.46 mL
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    SHIPPING AND STORAGE
    Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.