Product Data Sheet
Rebaudioside A
Catalog No. A12108
Rebaudioside A is an α-glucosidase inhibitor that demonstrates an IC50 value of 35.01 μg/mL. This steviol glycoside enhances insulin secretion in pancreatic β cells through a glucose-dependent mechanism, which involves the inhibition of KATP channels and subsequent depolarization and calcium influx. Additionally, Rebaudioside A regulates cholesterol metabolism by activating the SREBP signaling pathway and inhibiting HMGCR, leading to increased LDL receptor expression. It is suitable for research in the areas of blood glucose and lipid regulation, as well as obesity management.
Chemical Information
| Catalog Num | A12108 |
|---|---|
| M. Wt | 967.01 |
| Formula | C44H70O23 |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 58543-16-1 |
| Synonyms | |
| SMILES | C[C@]12[C@@]3([H])[C@@](C4)(CC[C@]1([H])[C@@](C)(CCC2)C(O[C@@H]5O[C@@H]([C@@H](O)[C@H](O)[C@H]5O)CO)=O)C[C@@](C4=C)(O[C@@]6([H])[C@@H]([C@H]([C@H](O)[C@@H](CO)O6)O[C@]7([H])O[C@@H]([C@@H](O)[C@H](O)[C@H]7O)CO)O[C@]8([H])O[C@@H]([C@@H](O)[C@H](O)[C@H]8O)CO)CC3 |
Biological Activity
| Description | Rebaudioside A is an α-glucosidase inhibitor that demonstrates an IC50 value of 35.01 μg/mL. This steviol glycoside enhances insulin secretion in pancreatic β cells through a glucose-dependent mechanism, which involves the inhibition of KATP channels and subsequent depolarization and calcium influx. Additionally, Rebaudioside A regulates cholesterol metabolism by activating the SREBP signaling pathway and inhibiting HMGCR, leading to increased LDL receptor expression. It is suitable for research in the areas of blood glucose and lipid regulation, as well as obesity management. |
|---|
RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
