Product Data Sheet

Cilengitide trifluoroacetate

Catalog No. A12371

main product photo
Cilengitide is a cyclic Arg-Gly-Asp peptide with potential antineoplastic activity. Cilengitide binds to and inhibits the activities of the alpha(v)beta(3) and alpha(v)beta(5) integrins, thereby inhibiting endothelial cell-cell interactions, endothelial cell-matrix interactions, and angiogenesis.
Adooq's Cilengitide trifluoroacetate has been cited by 1 publications
  • Yi Han Tan, .et al. , Cell Microbiol, 2017, Aug;19(8) PMID: 28186697
    • Chemical Information
    Catalog Num A12371
    M. Wt 702.7
    Formula C29H41N8O9F3
    Purity >98%
    Storage at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base)
    CAS No. 199807-35-7
    Synonyms EMD 12197,EMD-85189,EMD-121974,NSC-707544,D03497
    SMILES CC(C)[C@H]1C(=O)N[C@H](C(=O)NCC(=O)N[C@H](C(=O)N[C@@H](C(=O)N1C)Cc2ccccc2)CC(=O)O)CCCNC(=N)N.C(=O)(C(F)(F)F)O
    Storage

    Store lyophilized at -20ºC, keep desiccated.
    In lyophilized form, the chemical is stable for 36 months.
    In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.
    Biological Activity
    Discription Cilengitide is a cyclic Arg-Gly-Asp peptide with potential antineoplastic activity. Cilengitide binds to and inhibits the activities of the alpha(v)beta(3) and alpha(v)beta(5) integrins, thereby inhibiting endothelial cell-cell interactions, endothelial cell-matrix interactions, and angiogenesis.
    Targets
    Target Value
    Solubility
    In vitro DMSO 89 mg/mL (126.66 mM)
    Water 7 mg/mL (9.96 mM)
    Ethanol Insoluble
    * <1 mg/ml means slightly soluble or insoluble.
    * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
    Preparing Stock Solutions
    Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
    0.1 mM 14.23 mL 71.15 mL 142.31 mL
    0.5 mM 2.85 mL 14.23 mL 28.46 mL
    1 mM 1.42 mL 7.12 mL 14.23 mL
    5 mM 0.28 mL 1.42 mL 2.85 mL
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    SHIPPING AND STORAGE
    Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.