Product Data Sheet

MKC3946

Catalog No. A12508

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MKC3946 is a potent and soluble IRE1α inhibitor, used for cancer research.
Adooq's MKC3946 has been cited by 1 publications
  • Shengji Li, .et al. , Cancer Gene Ther, 2025, Aug;32(8):884-898 PMID: 40634594
  • Chemical Information
    Catalog NumA12508
    M. Wt380.46
    FormulaC21H20N2O3S
    Purity>98%
    Storageat -20 °C 3 years (powder form); at -20 °C 6 months (Solution base)
    CAS No.1093119-54-0
    SynonymsMKC 3946, MKC-3946
    SMILESO=CC1=C(O)C=CC2=C1C=CC(C3=CC=C(C(N4CCN(C)CC4)=O)S3)=C2
    Biological Activity
    DescriptionMKC3946 is a potent and soluble IRE1α inhibitor, used for cancer research.
    Solubility
    In vitro DMSO35 mg/mL (91.99 mM)
    WaterInsoluble
    Ethanol3 mg/mL (7.88 mM)
    * <1 mg/ml means slightly soluble or insoluble.
    * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
    Preparing Stock Solutions
    Concentration / Solvent Volume / Mass1 mg5 mg10 mg
    0.1 mM26.28 mL131.42 mL262.84 mL
    0.5 mM5.26 mL26.28 mL52.57 mL
    1 mM2.63 mL13.14 mL26.28 mL
    5 mM0.53 mL2.63 mL5.26 mL
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    SHIPPING AND STORAGE
    Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.