Product Data Sheet

PJ 34 hydrochloride

Catalog No. A12665

main product photo
PJ 34 hydrochloride is a potent inhibitor of poly(ADP-ribose) polymerase (PARP) (EC50 = 20 nM).
Adooq's PJ 34 hydrochloride has been cited by 2 publications
  • Wigle TJ, .et al. , SLAS Discov, 2019, Dec 19:2472555219883623 PMID: 31855104
  • Alvin Z.Lu, .et al. , Biochem Pharmacol, 2019, May 7. pii: S0006-2952(19)30171-6 PMID: 31075269
  • Chemical Information
    Catalog Num A12665
    M. Wt 331.8
    Formula C17H17N3O2.HCl
    Purity >98%
    Storage at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base)
    CAS No. 344458-15-7
    Synonyms PJ34, PJ-34
    SMILES CN(C)CC(=O)NC1=CC2=C(C=C1)NC(=O)C3=CC=CC=C32.Cl
    Storage

    Store lyophilized at -20ºC, keep desiccated.
    In lyophilized form, the chemical is stable for 36 months.
    In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

    Biological Activity
    Discription PJ 34 hydrochloride is a potent inhibitor of poly(ADP-ribose) polymerase (PARP) (EC50 = 20 nM).
    Targets
    Target Value
    Solubility
    In vitro (25°C) DMSO 57 mg/mL (171.79 mM)
    Water 57 mg/mL (171.79 mM)
    Ethanol Insoluble
    In vivo 30% PEG400+0.5% Tween80+5% propylene glycol 14 mg/mL
    * <1 mg/ml means slightly soluble or insoluble.
    * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
    Preparing Stock Solutions
    Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
    0.1 mM 30.14 mL 150.69 mL 301.39 mL
    0.5 mM 6.03 mL 30.14 mL 60.28 mL
    1 mM 3.01 mL 15.07 mL 30.14 mL
    5 mM 0.6 mL 3.01 mL 6.03 mL
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    SHIPPING AND STORAGE
    Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.