Product Data Sheet

PJ 34 hydrochloride

Catalog No. A12665

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PJ 34 hydrochloride is a potent inhibitor of poly(ADP-ribose) polymerase (PARP) (EC50 = 20 nM).
Adooq's PJ 34 hydrochloride has been cited by 2 publications
  • Wigle TJ, .et al. , SLAS Discov, 2019, Dec 19:2472555219883623 PMID: 31855104
  • Alvin Z.Lu, .et al. , Biochem Pharmacol, 2019, May 7. pii: S0006-2952(19)30171-6 PMID: 31075269
  • Chemical Information
    Catalog NumA12665
    M. Wt331.8
    FormulaC17H17N3O2.HCl
    Purity>98%
    Storageat -20 °C 3 years (powder form); at -20 °C 6 months (Solution base)
    CAS No.344458-15-7
    SynonymsPJ34, PJ-34
    SMILESCN(C)CC(=O)NC1=CC2=C(C=C1)NC(=O)C3=CC=CC=C32.Cl
    Biological Activity
    DescriptionPJ 34 hydrochloride is a potent inhibitor of poly(ADP-ribose) polymerase (PARP) (EC50 = 20 nM).
    Targets
    TargetValue
    Solubility
    In vitro (25°C) DMSO57 mg/mL (171.79 mM)
    Water57 mg/mL (171.79 mM)
    EthanolInsoluble
    In vivo 30% PEG400+0.5% Tween80+5% propylene glycol 14 mg/mL
    * <1 mg/ml means slightly soluble or insoluble.
    * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
    Preparing Stock Solutions
    Concentration / Solvent Volume / Mass1 mg5 mg10 mg
    0.1 mM30.14 mL150.69 mL301.39 mL
    0.5 mM6.03 mL30.14 mL60.28 mL
    1 mM3.01 mL15.07 mL30.14 mL
    5 mM0.6 mL3.01 mL6.03 mL
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    SHIPPING AND STORAGE
    Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.