Product Data Sheet

EPZ-6438 (Tazemetostat)

Catalog No. A12712

main product photo
EPZ-6438 is a potent, selective, and orally bioavailable small-molecule inhibitor of EZH2 enzymatic activity. It induces apoptosis and differentiation specifically in SMARCB1-deleted MRT cells.
Adooq's EPZ-6438 (Tazemetostat) has been cited by 3 publications
  • Yang PM, .et al. , Am J Cancer Res, 2019, Oct 1;9(10):2120-2139 PMID: 31720078
  • Wang Z, .et al. , J Cell Mol Med, 2019, May 13 PMID: 31087496
  • Theresa Baker, .et al. , Oncotarget, 2015, Oct 20; 6(32): 32646-32655 PMID: 26360609
    • Chemical Information
    Catalog Num A12712
    M. Wt 572.74
    Formula C34H44N4O4
    Purity >98%
    Storage at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base)
    CAS No. 1403254-99-8
    Synonyms EPZ6438, EPZ 6438
    SMILES CCN(C1CCOCC1)C2=CC(=CC(=C2C)C(=O)NCC3=C(C=C(NC3=O)C)C)C4=CC=C(C=C4)CN5CCOCC5
    Storage

    Store lyophilized at -20ºC, keep desiccated.
    In lyophilized form, the chemical is stable for 36 months.
    In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.
    Biological Activity
    Discription EPZ-6438 is a potent, selective, and orally bioavailable small-molecule inhibitor of EZH2 enzymatic activity. It induces apoptosis and differentiation specifically in SMARCB1-deleted MRT cells.
    Targets
    Target Value
    Solubility
    In vitro (25°C) DMSO Warmed: 4 mg/mL (6.98 mM)
    Water Insoluble
    Ethanol Insoluble
    In vivo 4% DMSO+30% PEG 300+5% Tween 80+ddH2O 2.3 mg/mL
    * <1 mg/ml means slightly soluble or insoluble.
    * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
    Preparing Stock Solutions
    Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
    0.1 mM 17.46 mL 87.3 mL 174.6 mL
    0.5 mM 3.49 mL 17.46 mL 34.92 mL
    1 mM 1.75 mL 8.73 mL 17.46 mL
    5 mM 0.35 mL 1.75 mL 3.49 mL
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    SHIPPING AND STORAGE
    Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.