Product Data Sheet

C646

Catalog No. A12815

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C646 is a selective p300/CREB-binding protein (CBP) inhibitor (Ki = 400 nM).
Adooq's C646 has been cited by 2 publications
  • Thibaud Reyser, .et al. , Pharmaceutics, 2023, Oct 10;15(10):2440 PMID: 37896200
  • Zhifeng Zhang, .et al. , PLoS One, 2017, 12(10): e0186900 PMID: 29049411
  • Chemical Information
    Catalog NumA12815
    M. Wt445.42
    FormulaC24H19N3O6
    Purity>98%
    Storageat -20 °C 3 years (powder form); at -20 °C 6 months (Solution base)
    CAS No.328968-36-1
    SynonymsC 646, C-646
    SMILESCC1=C(C=C(C(=C1)C2=CC=C(O2)/C=C\3/C(=NN(C3=O)C4=CC=C(C=C4)C(=O)O)C)[N+](=O)[O-])C
    Biological Activity
    DescriptionC646 is a selective p300/CREB-binding protein (CBP) inhibitor (Ki = 400 nM).
    Targets
    TargetValue
    Solubility
    In vitro (25°C) DMSO13 mg/mL (29.18 mM)
    WaterInsoluble
    EthanolInsoluble
    In vivo 5% DMSO+40% PEG 300+5%Tween 80+ddH2O 1 mg/mL
    * <1 mg/ml means slightly soluble or insoluble.
    * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
    Preparing Stock Solutions
    Concentration / Solvent Volume / Mass1 mg5 mg10 mg
    0.1 mM22.45 mL112.25 mL224.51 mL
    0.5 mM4.49 mL22.45 mL44.9 mL
    1 mM2.25 mL11.23 mL22.45 mL
    5 mM0.45 mL2.25 mL4.49 mL
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    SHIPPING AND STORAGE
    Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.