Product Data Sheet

Thiamet G

Catalog No. A12895

main product photo
Thiamet G is a potent, selective O-GlcNAcase inhibitor with Kiof 21 nM, while exhibiting 37,000-fold selectivity over human lysosomal-hexosaminidase.
Adooq's Thiamet G has been cited by 3 publications
  • Kefan Wu, .et al. , Biomedicines, 2023, Apr 24;11(5):1259 PMID: 37238930
  • Wei Zhong Zhu, .et al. , PLoS One, 2022, Oct 26;17(10):e0276285 PMID: 36288343
  • Zhu WZ, .et al. , J Am Heart Assoc, 2019, Jun 4;8(11):e011260 PMID: 31131693
    • Chemical Information
    Catalog Num A12895
    M. Wt 248.3
    Formula C9H16N2O4S
    Purity >98%
    Storage at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base)
    CAS No. 1009816-48-1
    Synonyms
    SMILES CCNC1=NC2C(C(C(OC2S1)CO)O)O
    Storage

    Store lyophilized at -20ºC, keep desiccated.
    In lyophilized form, the chemical is stable for 36 months.
    In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.
    Biological Activity
    Discription Thiamet G is a potent, selective O-GlcNAcase inhibitor with Kiof 21 nM, while exhibiting 37,000-fold selectivity over human lysosomal-hexosaminidase.
    Targets
    Target Value
    Solubility
    In vitro (25°C) DMSO 47 mg/mL (189.28 mM)
    Water 47 mg/mL (189.28 mM)
    Ethanol 11 mg/mL (44.29 mM)
    In vivo Saline 28 mg/mL
    * <1 mg/ml means slightly soluble or insoluble.
    * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
    Preparing Stock Solutions
    Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
    0.1 mM 40.27 mL 201.37 mL 402.74 mL
    0.5 mM 8.05 mL 40.27 mL 80.55 mL
    1 mM 4.03 mL 20.14 mL 40.27 mL
    5 mM 0.81 mL 4.03 mL 8.05 mL
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    SHIPPING AND STORAGE
    Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.