Product Data Sheet

PD 123319 ditrifluoroacetate

Catalog No. A13201

main product photo
PD 123319 ditrifluoroacetate is a potent, selective, non-peptide angiotensin AT2 receptor antagonist. IC50 values are 34 and 210 nM in rat adrenal tissue and brain respectively.
Adooq's PD 123319 ditrifluoroacetate has been cited by 1 publications
  • Dao-Lai Zhang, .et al. , eLife, 2018, 7: e33432 PMID: 29393851
    • Chemical Information
    Catalog Num A13201
    M. Wt 736.67
    Formula C31H32N4O3.2CF3CO2H
    Purity >98%
    Storage at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base)
    CAS No. 136676-91-0 (TFA), 130663-39-7
    Synonyms PD123319, PD-123319
    SMILES CC1=C(C=CC(=C1)CN2C=NC3=C2CC(N(C3)C(=O)C(C4=CC=CC=C4)C5=CC=CC=C5)C(=O)O)N(C)C.C(=O)(C(F)(F)F)O.C(=O)(C(F)(F)F)O
    Storage

    Store lyophilized at -20ºC, keep desiccated.
    In lyophilized form, the chemical is stable for 36 months.
    In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.
    Biological Activity
    Discription PD 123319 ditrifluoroacetate is a potent, selective, non-peptide angiotensin AT2 receptor antagonist. IC50 values are 34 and 210 nM in rat adrenal tissue and brain respectively.
    Targets
    Target Value
    Solubility
    In vitro (25°C) DMSO 87 mg/mL (171.05 mM)
    Water 87 mg/mL (171.05 mM)
    Ethanol 87 mg/mL (171.05 mM)
    In vivo Saline 28 mg/mL
    * <1 mg/ml means slightly soluble or insoluble.
    * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
    Preparing Stock Solutions
    Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
    0.1 mM 13.57 mL 67.87 mL 135.75 mL
    0.5 mM 2.71 mL 13.57 mL 27.15 mL
    1 mM 1.36 mL 6.79 mL 13.57 mL
    5 mM 0.27 mL 1.36 mL 2.71 mL
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    SHIPPING AND STORAGE
    Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.