Product Data Sheet

GSK2656157

Catalog No. A13577

main product photo
GSK2656157 is an ATP-competitive inhibitor of PERK enzyme activity with an IC(50) of 0.9 nmol/L. It is highly selective for PERK with IC(50) values >100 nmol/L against a panel of 300 kinases.
Adooq's GSK2656157 has been cited by 3 publications
  • Jun Liu, .et al. , Food Chem, 2023, Jun 30;412:135550 PMID: 36706507
  • Cao W, .et al. , J Cell Mol Med, 2019, Aug 23 PMID: 31441588
  • Kosuke Ishikawa, .et al. , Biology Methods and Protocols, 2018, 1-10
    • Chemical Information
    Catalog Num A13577
    M. Wt 416.45
    Formula C23H21FN6O
    Purity >98%
    Storage at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base)
    CAS No. 1337532-29-2
    Synonyms GSK 2656157
    SMILES CC1=NC(=CC=C1)CC(=O)N2CCC3=C2C=CC(=C3F)C4=CN(C5=C4C(=NC=N5)N)C
    Storage

    Store lyophilized at -20ºC, keep desiccated.
    In lyophilized form, the chemical is stable for 36 months.
    In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.
    Biological Activity
    Discription GSK2656157 is an ATP-competitive inhibitor of PERK enzyme activity with an IC(50) of 0.9 nmol/L. It is highly selective for PERK with IC(50) values >100 nmol/L against a panel of 300 kinases.
    Targets
    Target Value
    Solubility
    In vitro (25°C) DMSO 28 mg/mL (67.23 mM)
    Water Insoluble
    Ethanol Insoluble
    In vivo 1% CMC Na 28 mg/mL
    * <1 mg/ml means slightly soluble or insoluble.
    * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
    Preparing Stock Solutions
    Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
    0.1 mM 24.01 mL 120.06 mL 240.12 mL
    0.5 mM 4.8 mL 24.01 mL 48.02 mL
    1 mM 2.4 mL 12.01 mL 24.01 mL
    5 mM 0.48 mL 2.4 mL 4.8 mL
    RETURN POLICY
    Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
    SHIPPING AND STORAGE
    Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.