Product Data Sheet

FR 180204

Catalog No. A14119

main product photo
FR 180204 is a novel and selective inhibitor of extracellular signal-regulated kinase (ERK), which may be a potential new therapy for rheumatoid arthritis.
Adooq's FR 180204 has been cited by 2 publications
  • Sergey A Dyshlovoy, .et al. , Sci Rep, 2020, Aug 6;10(1):13178 PMID: 32764580
  • Dyshlovoy SA, .et al. , Proteomics, 2017, Jun;17(11) PMID: 28445005
  • Chemical Information
    Catalog Num A14119
    M. Wt 327.34
    Formula C18H13N7
    Purity >98%
    Storage at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base)
    CAS No. 865362-74-9
    Synonyms FR-180204,FR180204
    SMILES C1=CC=C(C=C1)C2=NN3C=CC=CC3=C2C4=CC5=C(NN=C5N=N4)N
    Storage

    Store lyophilized at -20ºC, keep desiccated.
    In lyophilized form, the chemical is stable for 36 months.
    In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

    Biological Activity
    Discription FR 180204 is a novel and selective inhibitor of extracellular signal-regulated kinase (ERK), which may be a potential new therapy for rheumatoid arthritis.
    Targets
    Target Value
    Solubility
    In vitro DMSO 57 mg/mL (174.13 mM)
    Water Insoluble
    Ethanol Warmed: 2 mg/mL (6.1 mM)
    * <1 mg/ml means slightly soluble or insoluble.
    * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
    Preparing Stock Solutions
    Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
    0.1 mM 30.55 mL 152.75 mL 305.49 mL
    0.5 mM 6.11 mL 30.55 mL 61.1 mL
    1 mM 3.05 mL 15.27 mL 30.55 mL
    5 mM 0.61 mL 3.05 mL 6.11 mL
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    SHIPPING AND STORAGE
    Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.