Product Data Sheet
Curdione
Catalog No. A14472
Curdione, a naturally occurring sesquiterpenoid, exhibits significant anti-platelet aggregation activity and plays a pivotal role in modulating ferroptosis in colorectal cancer through m6A methylation processes involving METTL14 and YTHDF2. This compound is effective in alleviating myocardial infarction-induced oxidative stress via the Keap1/Trx1/GPX4 signaling pathway and mitigating Doxorubicin-induced cardiotoxicity through activation of the Nrf2/HO-1 pathway. Additionally, Curdione demonstrates protective properties against sepsis-induced lung injury, pulmonary fibrosis, and focal cerebral ischemia, while also exhibiting antiproliferative effects against human uterine leiomyosarcoma by targeting IDO1. Its modulation of DNMT1-mediated ERBB4 promoter methylation further supports its vascular protective effects.
Chemical Information
| Catalog Num | A14472 |
|---|---|
| M. Wt | 236.35 |
| Formula | C15H24O2 |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 13657-68-6 |
| Synonyms | (+)-Curdione |
| SMILES | O=C1C[C@@H](C(C)C)C(C/C(C)=C/CC[C@@H]1C)=O |
Biological Activity
| Description | Curdione, a naturally occurring sesquiterpenoid, exhibits significant anti-platelet aggregation activity and plays a pivotal role in modulating ferroptosis in colorectal cancer through m6A methylation processes involving METTL14 and YTHDF2. This compound is effective in alleviating myocardial infarction-induced oxidative stress via the Keap1/Trx1/GPX4 signaling pathway and mitigating Doxorubicin-induced cardiotoxicity through activation of the Nrf2/HO-1 pathway. Additionally, Curdione demonstrates protective properties against sepsis-induced lung injury, pulmonary fibrosis, and focal cerebral ischemia, while also exhibiting antiproliferative effects against human uterine leiomyosarcoma by targeting IDO1. Its modulation of DNMT1-mediated ERBB4 promoter methylation further supports its vascular protective effects. |
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RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
