Product Data Sheet

Wedelolactone

Catalog No. A14804

main product photo
Wedelolactone, a compound originally extracted from Eclipta alba, has been shown to inhibit caspase-11, which is a key regulator of proinflammatory cytokine IL-1β maturation and pathological apoptosis.
Adooq's Wedelolactone has been cited by 1 publications
  • Shigetoshi Yokoyama, .et al. , eLife, 2018, 7: e37854 PMID: 30526845
  • Chemical Information
    Catalog Num A14804
    M. Wt 314.3
    Formula C16H10O7
    Purity >98%
    Storage at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base)
    CAS No. 524-12-9
    Synonyms IKK Inhibitor II, Eclipta alba
    SMILES COC1=CC(=C2C(=C1)OC(=O)C3=C2OC4=CC(=C(C=C43)O)O)O
    Storage

    Store lyophilized at -20ºC, keep desiccated.
    In lyophilized form, the chemical is stable for 36 months.
    In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

    Biological Activity
    Discription Wedelolactone, a compound originally extracted from Eclipta alba, has been shown to inhibit caspase-11, which is a key regulator of proinflammatory cytokine IL-1β maturation and pathological apoptosis.
    Targets
    Target Value
    Solubility
    In vitro DMSO 60 mg/mL (190.92 mM)
    * <1 mg/ml means slightly soluble or insoluble.
    * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
    Preparing Stock Solutions
    Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
    0.1 mM 31.82 mL 159.08 mL 318.17 mL
    0.5 mM 6.36 mL 31.82 mL 63.63 mL
    1 mM 3.18 mL 15.91 mL 31.82 mL
    5 mM 0.64 mL 3.18 mL 6.36 mL
    RETURN POLICY
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    SHIPPING AND STORAGE
    Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.