Product Data Sheet

Q-VD-OPh hydrate

Catalog No. A14915

main product photo
Q-VD-OPH is a selective, brain and cell permeable, highly potent and irreversible inhibitor of caspase-3 ( IC50=25nm), caspase-1 (IC50=50nM), caspase-8 (IC50=100nM) and caspase-9 (IC50=430nM).
Adooq's Q-VD-OPh hydrate has been cited by 4 publications
  • Anna L Koessinger, .et al. , Cell Death Differ, 2022, Apr 26 PMID: 35473984
  • Florian J Bock, .et al. , Nat Commun, 2021, Nov 12;12(1):6572 PMID: 34772930
  • Davide Pradella, .et al. , Nat Commun, 2021, 12: 4872 PMID: 34381052
  • Haschka MD, .et al. , Cell Death Differ, 2020, Feb 3 PMID: 32015503
    • Chemical Information
    Catalog Num A14915
    M. Wt 513.49
    Formula C26H25F2N3O6
    Purity >98%
    Storage at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base)
    CAS No. 1135695-98-5
    Synonyms
    SMILES CC(C)C(C(=O)NC(CC(=O)O)C(=O)COC1=C(C=CC=C1F)F)NC(=O)C2=NC3=CC=CC=C3C=C2
    Storage

    Store lyophilized at -20ºC, keep desiccated.
    In lyophilized form, the chemical is stable for 36 months.
    In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.
    Biological Activity
    Discription Q-VD-OPH is a selective, brain and cell permeable, highly potent and irreversible inhibitor of caspase-3 ( IC50=25nm), caspase-1 (IC50=50nM), caspase-8 (IC50=100nM) and caspase-9 (IC50=430nM).
    Targets
    Target Value
    Solubility
    In vitro DMSO 94 mg/mL (183.06 mM)
    Water Insoluble
    Ethanol 94 mg/mL (183.06 mM)
    * <1 mg/ml means slightly soluble or insoluble.
    * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
    Preparing Stock Solutions
    Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
    0.1 mM 19.47 mL 97.37 mL 194.75 mL
    0.5 mM 3.89 mL 19.47 mL 38.95 mL
    1 mM 1.95 mL 9.74 mL 19.47 mL
    5 mM 0.39 mL 1.95 mL 3.89 mL
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    SHIPPING AND STORAGE
    Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.