Product Data Sheet
Bullatine A
Catalog No. A15587
Bullatine A is a potent P2X7 antagonist with significant anti-inflammatory and anti-nociceptive properties. It effectively inhibits ATP-induced BV-2 cell apoptosis and modulates inflammatory responses mediated by P2X receptors. Bullatine A has demonstrated the ability to reduce glioma cell growth by targeting SIRT6, alleviate pain hypersensitivity in rodent models, and mitigate systemic inflammation via the ROS/JNK/NF-κB pathway. Additionally, it has shown potential in improving behavioral outcomes in models of chronic social defeat stress. This compound is valuable for research in inflammation, glioblastoma, and depression.
Chemical Information
| Catalog Num | A15587 |
|---|---|
| M. Wt | 343.50 |
| Formula | C22H33NO2 |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 1354-84-3 |
| Synonyms | |
| SMILES | O[C@H](C1C2([C@@H]3O)C4C[C@]5([H])[C@@]6(C)CCCC51C4N(CC)C6)C(CC2)C3=C |
Biological Activity
| Description | Bullatine A is a potent P2X7 antagonist with significant anti-inflammatory and anti-nociceptive properties. It effectively inhibits ATP-induced BV-2 cell apoptosis and modulates inflammatory responses mediated by P2X receptors. Bullatine A has demonstrated the ability to reduce glioma cell growth by targeting SIRT6, alleviate pain hypersensitivity in rodent models, and mitigate systemic inflammation via the ROS/JNK/NF-κB pathway. Additionally, it has shown potential in improving behavioral outcomes in models of chronic social defeat stress. This compound is valuable for research in inflammation, glioblastoma, and depression. |
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RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
