Product Data Sheet
Talatisamine
Catalog No. A15618
Talatisamine is an orally active cyclophilin D activator derived from the roots of Aconitum carmichaeli Debx. It functions primarily by preventing calcium-dependent opening of the mitochondrial permeability transition pore (mPTP) with an IC50 of 78 μM and inhibiting delayed rectifier K+ channels with an IC50 of 146 μM. Talatisamine demonstrates significant antioxidant and membrane-stabilizing properties, effectively inhibiting lipid peroxidation and preserving mitochondrial membrane integrity. Its diverse biological activities include antiarrhythmic, hypotensive, anti-inflammatory, anticancer, and neuroprotective effects, making it a valuable tool in the study of ischemic diseases, rheumatoid arthritis, inflammation-related conditions, and Alzheimer's disease.
Chemical Information
| Catalog Num | A15618 |
|---|---|
| M. Wt | 421.57 |
| Formula | C24H39NO5 |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 20501-56-8 |
| Synonyms | |
| SMILES | CO[C@@H]1C(C(N(CC)C2)C3C4)([C@@](C[C@@]5([H])[C@@H]6O)([H])[C@@]6([H])[C@@]3(C[C@@H]5OC)O)[C@@]4([H])[C@@]2(COC)CC1 |
Biological Activity
| Description | Talatisamine is an orally active cyclophilin D activator derived from the roots of Aconitum carmichaeli Debx. It functions primarily by preventing calcium-dependent opening of the mitochondrial permeability transition pore (mPTP) with an IC50 of 78 μM and inhibiting delayed rectifier K+ channels with an IC50 of 146 μM. Talatisamine demonstrates significant antioxidant and membrane-stabilizing properties, effectively inhibiting lipid peroxidation and preserving mitochondrial membrane integrity. Its diverse biological activities include antiarrhythmic, hypotensive, anti-inflammatory, anticancer, and neuroprotective effects, making it a valuable tool in the study of ischemic diseases, rheumatoid arthritis, inflammation-related conditions, and Alzheimer's disease. |
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RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
