Product Data Sheet
Aloin B
Catalog No. A15638
Aloin B (Isobarbaloin) is an orally active inhibitor of the SARS-CoV-2 papain-like protease (PLpro), with reported IC50 values of 16.08 μM for hydrolytic activity and 17.51 μM for deubiquitinase activity. This compound demonstrates biological activity in anti-inflammatory pathways and tumor promotion inhibition, making it valuable for research in cancer biology and COVID-19. Additionally, Aloin B is metabolized by intestinal flora to produce aloe-emodin-9-anthrone, which may contribute to its laxative effects.
Chemical Information
| Catalog Num | A15638 |
|---|---|
| M. Wt | 418.39 |
| Formula | C21H22O9 |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 28371-16-6 |
| Synonyms | Isobarbaloin |
| SMILES | O[C@H]([C@H]1O)[C@](O[C@H](CO)[C@H]1O)([H])[C@@](C2=CC=CC(O)=C23)([H])C(C=C(CO)C=C4O)=C4C3=O |
Biological Activity
| Description | Aloin B (Isobarbaloin) is an orally active inhibitor of the SARS-CoV-2 papain-like protease (PLpro), with reported IC50 values of 16.08 μM for hydrolytic activity and 17.51 μM for deubiquitinase activity. This compound demonstrates biological activity in anti-inflammatory pathways and tumor promotion inhibition, making it valuable for research in cancer biology and COVID-19. Additionally, Aloin B is metabolized by intestinal flora to produce aloe-emodin-9-anthrone, which may contribute to its laxative effects. |
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RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
