Product Data Sheet

CAY10603

Catalog No. A16431

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CAY10603 is a potent and selective HDAC6 inhibitor with IC50 of 2 pM, >200-fold selectivity over other HDACs.
Adooq's CAY10603 has been cited by 1 publications
  • Isin Cakir, .et al. , Nat Metab, 2022, Jan;4(1):44-59 PMID: 35039672
  • Chemical Information
    Catalog Num A16431
    M. Wt 446.5
    Formula C22H30N4O6
    Purity >98%
    Storage at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base)
    CAS No. 1045792-66-2
    Synonyms CAY-10603, CAY 10603
    SMILES CC(C)(C)OC(=O)NC1=CC=C(C=C1)C2=CC(=NO2)C(=O)NCCCCCCC(=O)NO
    Storage

    Store lyophilized at -20ºC, keep desiccated.
    In lyophilized form, the chemical is stable for 36 months.
    In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

    Biological Activity
    Discription CAY10603 is a potent and selective HDAC6 inhibitor with IC50 of 2 pM, >200-fold selectivity over other HDACs.
    Targets
    Target Value
    Solubility
    In vitro (25°C) DMSO 88 mg/mL (197.08 mM)
    Water Insoluble
    Ethanol Warmed: 5 mg/mL
    In vivo 5% DMSO+50% PEG 300+ddH2O 8 mg/mL
    * <1 mg/ml means slightly soluble or insoluble.
    * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
    Preparing Stock Solutions
    Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
    0.1 mM 22.4 mL 111.98 mL 223.96 mL
    0.5 mM 4.48 mL 22.4 mL 44.79 mL
    1 mM 2.24 mL 11.2 mL 22.4 mL
    5 mM 0.45 mL 2.24 mL 4.48 mL
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    SHIPPING AND STORAGE
    Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.