Product Data Sheet
Naratriptan hydrochloride
Catalog No. A16629
Naratriptan hydrochloride is a selective agonist for the 5-HT1B and 5-HT1D receptors. It effectively induces vasoconstriction of cranial arteries through these receptor pathways, demonstrating an EC50 value of 0.11 μM in dog basilar artery models. Additionally, Naratriptan hydrochloride exhibits the ability to inhibit trigeminal nerve-mediated dural neurogenic plasma extravasation and mitigate sterile inflammation. This compound is primarily utilized in research focused on acute migraine, particularly in the investigation of cranial vascular and neuroinflammatory mechanisms.
Chemical Information
| Catalog Num | A16629 |
|---|---|
| M. Wt | 371.93 |
| Formula | C17H26ClN3O2S |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 143388-64-1 |
| Synonyms | GR-85548A hydrochloride |
| SMILES | O=S(CCC1=CC2=C(NC=C2C3CCN(C)CC3)C=C1)(NC)=O.Cl |
Biological Activity
| Description | Naratriptan hydrochloride is a selective agonist for the 5-HT1B and 5-HT1D receptors. It effectively induces vasoconstriction of cranial arteries through these receptor pathways, demonstrating an EC50 value of 0.11 μM in dog basilar artery models. Additionally, Naratriptan hydrochloride exhibits the ability to inhibit trigeminal nerve-mediated dural neurogenic plasma extravasation and mitigate sterile inflammation. This compound is primarily utilized in research focused on acute migraine, particularly in the investigation of cranial vascular and neuroinflammatory mechanisms. |
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RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
