Product Data Sheet
Sulfathiazole
Catalog No. A16733
Sulfathiazole is an antibiotic with notable activity as an endocrine disruptor, primarily targeting the steroidogenic pathway by enhancing CYP19 activity in human adrenal cancer cells (H295R). This compound also upregulates the mRNA expression of CYP17, CYP19, and 3β-HSD, leading to increased production of 17-estradiol (E2). Additionally, sulfathiazole demonstrates endocrine-disrupting effects in aquatic organisms, such as the Japanese medaka fish, making it relevant for studies in environmental toxicology and endocrine disruption research.
Chemical Information
| Catalog Num | A16733 |
|---|---|
| M. Wt | 255.32 |
| Formula | C9H9N3O2S2 |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 72-14-0 |
| Synonyms | |
| SMILES | O=S(C1=CC=C(N)C=C1)(NC2=NC=CS2)=O |
Biological Activity
| Description | Sulfathiazole is an antibiotic with notable activity as an endocrine disruptor, primarily targeting the steroidogenic pathway by enhancing CYP19 activity in human adrenal cancer cells (H295R). This compound also upregulates the mRNA expression of CYP17, CYP19, and 3β-HSD, leading to increased production of 17-estradiol (E2). Additionally, sulfathiazole demonstrates endocrine-disrupting effects in aquatic organisms, such as the Japanese medaka fish, making it relevant for studies in environmental toxicology and endocrine disruption research. |
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RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
