Product Data Sheet
Mepyramine maleate
Catalog No. A17387
Mepyramine maleate is a potent antagonist of the histamine H1 receptor, exhibiting a Kd of 0.8 nM for H1, alongside Kd values of 5200 nM and >3000 nM for H2 and H3 receptors, respectively. With a pKd value of 9.4 for the H1 receptor, this first-generation antihistamine is valuable for studies focused on allergic responses and the role of histamine in various physiological processes. It is widely used in pharmacological research to explore histamine-mediated signaling and potential therapeutic applications in allergy and inflammation.
Chemical Information
| Catalog Num | A17387 |
|---|---|
| M. Wt | 401.46 |
| Formula | C21H27N3O5 |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 59-33-6 |
| Synonyms | Pyrilamine maleate |
| SMILES | CN(C)CCN(CC1=CC=C(OC)C=C1)C2=NC=CC=C2.O=C(O)/C=C\C(O)=O |
Biological Activity
| Description | Mepyramine maleate is a potent antagonist of the histamine H1 receptor, exhibiting a Kd of 0.8 nM for H1, alongside Kd values of 5200 nM and >3000 nM for H2 and H3 receptors, respectively. With a pKd value of 9.4 for the H1 receptor, this first-generation antihistamine is valuable for studies focused on allergic responses and the role of histamine in various physiological processes. It is widely used in pharmacological research to explore histamine-mediated signaling and potential therapeutic applications in allergy and inflammation. |
|---|
RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
