Product Data Sheet
Trimipramine maleate
Catalog No. A17402
Trimipramine maleate is a selective 5-HT receptor antagonist that effectively crosses the blood-brain barrier. It demonstrates significant binding affinity with pKi values of 6.39, 8.10, and 4.66 for the 5-HT1C, 5-HT2, and 5-HT1A receptors, respectively. Additionally, Trimipramine maleate acts as an inhibitor of human noradrenaline transporter (hNAT), serotonin transporter (hSERT), and organic cation transporters (hOCT1, hOCT2), with IC50 values of 4.99 μM, 2.11 μM, and 3.72 μM, and 8.00 μM, respectively. Its unique pharmacological profile also indicates potential applications in vascular activity and anxiety treatment research.
Chemical Information
| Catalog Num | A17402 |
|---|---|
| M. Wt | 410.51 |
| Formula | C24H30N2O4 |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 521-78-8 |
| Synonyms | |
| SMILES | CC(CN(C)C)CN1C2=C(C=CC=C2)CCC3=C1C=CC=C3.O=C(O)/C=C\C(O)=O |
Biological Activity
| Description | Trimipramine maleate is a selective 5-HT receptor antagonist that effectively crosses the blood-brain barrier. It demonstrates significant binding affinity with pKi values of 6.39, 8.10, and 4.66 for the 5-HT1C, 5-HT2, and 5-HT1A receptors, respectively. Additionally, Trimipramine maleate acts as an inhibitor of human noradrenaline transporter (hNAT), serotonin transporter (hSERT), and organic cation transporters (hOCT1, hOCT2), with IC50 values of 4.99 μM, 2.11 μM, and 3.72 μM, and 8.00 μM, respectively. Its unique pharmacological profile also indicates potential applications in vascular activity and anxiety treatment research. |
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RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
