Product Data Sheet

Setiptiline maleate

Catalog No. A18091

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Setiptiline maleate is a serotonin receptor antagonist targeting multiple pathways in neurotransmitter regulation. As a tetracyclic antidepressant (TeCA), it functions primarily as a noradrenergic and specific serotonergic antidepressant (NaSSA), inhibiting norepinephrine reuptake and antagonizing α2-adrenergic receptors. Setiptiline maleate further interacts with serotonin receptor subtypes, including 5-HT2A, 5-HT2C, and/or 5-HT3, while also acting as an H1 receptor inverse agonist, demonstrating potential utility in depression and anxiety research.
Chemical Information
Catalog NumA18091
M. Wt377.43
FormulaC23H23NO4
Purity>98%
Storageat -20 °C 3 years (powder form); at -20 °C 6 months (Solution base)
CAS No.85650-57-3
SynonymsMO-8282
SMILESCN1CC(C(C=CC=C2)=C2C3)=C(CC1)C4=C3C=CC=C4.O=C(O)/C=C\C(O)=O
Biological Activity
DescriptionSetiptiline maleate is a serotonin receptor antagonist targeting multiple pathways in neurotransmitter regulation. As a tetracyclic antidepressant (TeCA), it functions primarily as a noradrenergic and specific serotonergic antidepressant (NaSSA), inhibiting norepinephrine reuptake and antagonizing α2-adrenergic receptors. Setiptiline maleate further interacts with serotonin receptor subtypes, including 5-HT2A, 5-HT2C, and/or 5-HT3, while also acting as an H1 receptor inverse agonist, demonstrating potential utility in depression and anxiety research.
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SHIPPING AND STORAGE
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