Product Data Sheet

Ropivacaine hydrochloride

Catalog No. A18119

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Ropivacaine hydrochloride is a potent sodium channel inhibitor that effectively disrupts impulse conduction by reversibly blocking sodium ion influx in nerve fibers. Additionally, it inhibits the K2P TREK-1 potassium channel with an IC50 of 402.7 μM in COS-7 cell membranes. This compound is primarily applied in the management of neuropathic pain in various in vivo research contexts.
Chemical Information
Catalog NumA18119
M. Wt310.86
FormulaC17H27ClN2O
Purity>98%
Storageat -20 °C 3 years (powder form); at -20 °C 6 months (Solution base)
CAS No.98717-15-8
Synonyms
SMILES[H]Cl.O=C([C@H]1N(CCC)CCCC1)NC2=C(C)C=CC=C2C
Biological Activity
DescriptionRopivacaine hydrochloride is a potent sodium channel inhibitor that effectively disrupts impulse conduction by reversibly blocking sodium ion influx in nerve fibers. Additionally, it inhibits the K2P TREK-1 potassium channel with an IC50 of 402.7 μM in COS-7 cell membranes. This compound is primarily applied in the management of neuropathic pain in various in vivo research contexts.
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