Product Data Sheet

Trametinib (DMSO solvate)

Catalog No. A21450

main product photo
Trametinib DMSO solvate (GSK-1120212 (DMSO solvate);JTP-74057 (DMSO solvate)) is a potent MEK inhibitor that specifically inhibits MEK1/2, with an IC50 value of about 2 nM.
Adooq's Trametinib (DMSO solvate) has been cited by 1 publications
  • Yuki Shimizu, .et al. , Cancer Lett, 2022, Sep 1;543 PMID: 35724767
  • Chemical Information
    Catalog Num A21450
    M. Wt 693.53
    Formula C28H29FIN5O5S
    Purity >98%
    Storage at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base)
    CAS No. 1187431-43-1
    Synonyms GSK-1120212 (DMSO solvate), GSK1120212, GSK 1120212; JTP-74057 (DMSO solvate), JTP74057, JTP 74057
    SMILES CN1C(C(C)=C(N(C(N(C2=O)C3CC3)=O)C4=CC=CC(NC(C)=O)=C4)C2=C1NC5=CC=C(C=C5F)I)=O.CS(C)=O
    Storage

    Store lyophilized at -20ºC, keep desiccated.
    In lyophilized form, the chemical is stable for 36 months.
    In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

    Biological Activity
    Discription Trametinib DMSO solvate (GSK-1120212 (DMSO solvate);JTP-74057 (DMSO solvate)) is a potent MEK inhibitor that specifically inhibits MEK1/2, with an IC50 value of about 2 nM.
    Targets
    Target Value
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    SHIPPING AND STORAGE
    Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.