Product Data Sheet
ERK-IN-4
Catalog No. A24156
ERK-IN-4 is a selective extracellular signal-regulated kinase (ERK) inhibitor that preferentially binds to ERK2 with a dissociation constant (K_d) of 5 μM. It specifically inhibits the phosphorylation of downstream ERK substrates, including Rsk-1 and Elk-1, without significantly affecting the phosphorylation of ERK itself by its upstream activators MEK1/2. This targeted mode of action allows ERK-IN-4 to modulate ERK signaling output without disrupting upstream pathway dynamics, making it a useful tool for studying ERK-mediated cellular processes and potential therapeutic intervention in ERK-driven diseases.
Chemical Information
| Catalog Num | A24156 |
|---|---|
| M. Wt | 328.81 |
| Formula | C14H17ClN2O3S |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 1049738-54-6 |
| Synonyms | |
| SMILES | O=C(N(CCN)C/1=O)SC1=C/C2=CC=C(OCC)C=C2.[H]Cl |
Biological Activity
| Description | ERK-IN-4 is a selective extracellular signal-regulated kinase (ERK) inhibitor that preferentially binds to ERK2 with a dissociation constant (K_d) of 5 μM. It specifically inhibits the phosphorylation of downstream ERK substrates, including Rsk-1 and Elk-1, without significantly affecting the phosphorylation of ERK itself by its upstream activators MEK1/2. This targeted mode of action allows ERK-IN-4 to modulate ERK signaling output without disrupting upstream pathway dynamics, making it a useful tool for studying ERK-mediated cellular processes and potential therapeutic intervention in ERK-driven diseases. |
|---|
RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
