Product Data Sheet
(rel)-AR234960
Catalog No. A24159
(rel)-AR234960 is a selective and competitive agonist of the MAS G protein-coupled receptor (GPCR), known for its role in cardiovascular regulation. Upon binding to the MAS receptor, (rel)-AR234960 activates the ERK1/2 signaling cascade, leading to the upregulation of connective tissue growth factor (CTGF) and downstream collagen subtype genes, including COL1A1 and COL3A1.
This activation promotes collagen synthesis in cardiac fibroblasts via the MAS–ERK1/2–CTGF axis, contributing to extracellular matrix remodeling and the progression of cardiac fibrosis. The fibrotic effects of (rel)-AR234960 can be reversed by the MAS inverse agonist AR244555 or by inhibition of MEK1, a key upstream regulator of ERK1/2.
This activation promotes collagen synthesis in cardiac fibroblasts via the MAS–ERK1/2–CTGF axis, contributing to extracellular matrix remodeling and the progression of cardiac fibrosis. The fibrotic effects of (rel)-AR234960 can be reversed by the MAS inverse agonist AR244555 or by inhibition of MEK1, a key upstream regulator of ERK1/2.
Chemical Information
| Catalog Num | A24159 |
|---|---|
| M. Wt | 555.62 |
| Formula | C27H30FN5O5S |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 1408311-94-3 |
| Synonyms | |
| SMILES | O=S(N1C[C@@H](CN2CCN(C3=NC=CC=C3)CC2)[C@H](C4=CC=CC(F)=C4)C1)(C5=CC=C([N+]([O-])=O)C=C5OC)=O |
Biological Activity
| Description | (rel)-AR234960 is a selective and competitive agonist of the MAS G protein-coupled receptor (GPCR), known for its role in cardiovascular regulation. Upon binding to the MAS receptor, (rel)-AR234960 activates the ERK1/2 signaling cascade, leading to the upregulation of connective tissue growth factor (CTGF) and downstream collagen subtype genes, including COL1A1 and COL3A1. This activation promotes collagen synthesis in cardiac fibroblasts via the MAS–ERK1/2–CTGF axis, contributing to extracellular matrix remodeling and the progression of cardiac fibrosis. The fibrotic effects of (rel)-AR234960 can be reversed by the MAS inverse agonist AR244555 or by inhibition of MEK1, a key upstream regulator of ERK1/2. |
|---|
RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
