Product Data Sheet
Pimethixene maleate
Catalog No. A24320
Pimethixene maleate is a potent antihistamine and antiserotonergic compound used as an antimigraine agent. It exhibits strong antagonistic activity at multiple receptors, including serotonin 5-HT1A (pKi 7.63), 5-HT2A (pKi 10.22), 5-HT2B (pKi 10.44), 5-HT2C (pKi 8.42), histamine H1 (pKi 10.14), dopamine D2 (pKi 8.19), dopamine D4.4 (pKi 7.54), muscarinic M1 (pKi 8.61), and muscarinic M2 (pKi 9.38) receptors. Its broad receptor-binding profile contributes to its therapeutic efficacy in migraine management.
Chemical Information
| Catalog Num | A24320 |
|---|---|
| M. Wt | 409.50 |
| Formula | C23H23NO4S |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 13187-06-9 |
| Synonyms | Pimetixene maleate |
| SMILES | CN1CC/C(CC1)=C2C3=C(SC4=C\2C=CC=C4)C=CC=C3.OC(/C=C\C(O)=O)=O |
Biological Activity
| Description | Pimethixene maleate is a potent antihistamine and antiserotonergic compound used as an antimigraine agent. It exhibits strong antagonistic activity at multiple receptors, including serotonin 5-HT1A (pKi 7.63), 5-HT2A (pKi 10.22), 5-HT2B (pKi 10.44), 5-HT2C (pKi 8.42), histamine H1 (pKi 10.14), dopamine D2 (pKi 8.19), dopamine D4.4 (pKi 7.54), muscarinic M1 (pKi 8.61), and muscarinic M2 (pKi 9.38) receptors. Its broad receptor-binding profile contributes to its therapeutic efficacy in migraine management. |
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RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
