Product Data Sheet
IDE397 (GSK-4362676)
Catalog No. A24329
IDE397 (GSK-4362676) is a potent and selective inhibitor of methionine adenosyltransferase 2A (MAT2A). It exhibits strong anti-tumor activity, particularly in patient-derived xenograft (PDX) models with MTAP (methylthioadenosine phosphorylase) deletion. By targeting MAT2A in MTAP-deficient tumors, IDE397 exploits a synthetic lethality approach, making it a promising candidate for precision oncology research.
Chemical Information
| Catalog Num | A24329 |
|---|---|
| M. Wt | 340.69 |
| Formula | C14H8ClF3N4O |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 2439277-80-0 |
| Synonyms | MAT2A-IN-9 |
| SMILES | O=C1N(C=2C(=CC=C(C(F)(F)F)N2)C(N)=N1)C3=C(Cl)C=CC=C3 |
Biological Activity
| Description | IDE397 (GSK-4362676) is a potent and selective inhibitor of methionine adenosyltransferase 2A (MAT2A). It exhibits strong anti-tumor activity, particularly in patient-derived xenograft (PDX) models with MTAP (methylthioadenosine phosphorylase) deletion. By targeting MAT2A in MTAP-deficient tumors, IDE397 exploits a synthetic lethality approach, making it a promising candidate for precision oncology research. |
|---|
RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
