Product Data Sheet
AG-270
Catalog No. A24330
AG-270 is a first-in-class, reversible, and orally active methionine adenosyltransferase 2A (MAT2A) inhibitor. It functions as an allosteric and noncompetitive inhibitor, with an IC₅₀ of 14 nM. AG-270 is being explored for its therapeutic potential in cancers with MTAP deletions, where MAT2A inhibition leads to selective antitumor effects via disruption of methylation-dependent processes.
Chemical Information
| Catalog Num | A24330 |
|---|---|
| M. Wt | 489.57 |
| Formula | C30H27N5O2 |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 2201056-66-6 |
| Synonyms | |
| SMILES | O=C1C(C2=CC=C(OC)C=C2)=C(NC3=NC=CC=C3)NC4=C(C5=CCCCC5)C(C6=CC=CC=C6)=NN14 |
Biological Activity
| Description | AG-270 is a first-in-class, reversible, and orally active methionine adenosyltransferase 2A (MAT2A) inhibitor. It functions as an allosteric and noncompetitive inhibitor, with an IC₅₀ of 14 nM. AG-270 is being explored for its therapeutic potential in cancers with MTAP deletions, where MAT2A inhibition leads to selective antitumor effects via disruption of methylation-dependent processes. |
|---|
RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
