Product Data Sheet

Naphthol AS-E

Catalog No. A24414

main product photo
Naphthol AS-E is a potent, cell-permeable inhibitor of the KIX-KID interaction. It binds directly to the KIX domain of CBP with a Kd of 8.6 μM and inhibits the interaction between the KIX domain and the KID domain of CREB with an IC₅₀ of 2.26 μM. Naphthol AS-E is applicable in cancer research.
Chemical Information
Catalog NumA24414
M. Wt297.74
FormulaC17H12ClNO2
Purity>98%
Storageat -20 °C 3 years (powder form); at -20 °C 6 months (Solution base)
CAS No.92-78-4
Synonyms
SMILESO=C(C1=C(O)C=C2C=CC=CC2=C1)NC3=CC=C(Cl)C=C3
Biological Activity
DescriptionNaphthol AS-E is a potent, cell-permeable inhibitor of the KIX-KID interaction. It binds directly to the KIX domain of CBP with a Kd of 8.6 μM and inhibits the interaction between the KIX domain and the KID domain of CREB with an IC₅₀ of 2.26 μM. Naphthol AS-E is applicable in cancer research.
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