Product Data Sheet
LYG-409
Catalog No. A24461
LYG-409 is an orally active degrader of GSPT1 that demonstrates potent antitumor activity in vivo, with tumor growth inhibition (TGI) rates of 94.34% in acute myeloid leukemia and 104.49% in prostate cancer models. In vitro, LYG-409 inhibits KG-1 cells through GSPT1 degradation, with an IC₅₀ of 9.50 nM and a DC₅₀ of 7.87 nM.
Chemical Information
| Catalog Num | A24461 |
|---|---|
| M. Wt | 515.44 |
| Formula | C25H20F3N3O6 |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 3053857-55-6 |
| Synonyms | |
| SMILES | O=C1N(CC2=C1C=CC(CNC(C3=CC4=C(OC3)C=CC(OC(F)(F)F)=C4)=O)=C2)C5CCC(NC5=O)=O |
Biological Activity
| Description | LYG-409 is an orally active degrader of GSPT1 that demonstrates potent antitumor activity in vivo, with tumor growth inhibition (TGI) rates of 94.34% in acute myeloid leukemia and 104.49% in prostate cancer models. In vitro, LYG-409 inhibits KG-1 cells through GSPT1 degradation, with an IC₅₀ of 9.50 nM and a DC₅₀ of 7.87 nM. |
|---|
RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
