Product Data Sheet
Deoxyshikonin
Catalog No. A24627
Deoxyshikonin is an antibacterial agent that exhibits significant activity against methicillin-resistant Staphylococcus aureus (MRSA) and Streptococcus pneumoniae, with a minimum inhibitory concentration (MIC) of 17 μg/mL. It enhances the expression of VEGF-C and VEGF-A mRNA in human microvascular endothelial cells, promotes the interaction of HIF-1α and HIF-1β subunits, and binds to specific DNA sequences associated with HIF. Additionally, Deoxyshikonin demonstrates proangiogenic and antitumor effects by inhibiting colorectal cancer via the PI3K/Akt/mTOR signaling pathway, making it valuable for both antibacterial and cancer research applications.
Chemical Information
| Catalog Num | A24627 |
|---|---|
| M. Wt | 272.30 |
| Formula | C16H16O4 |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 43043-74-9 |
| Synonyms | Arnebin 7 |
| SMILES | O=C1C(CC/C=C(C)/C)=CC(C2=C1C(O)=CC=C2O)=O |
Biological Activity
| Description | Deoxyshikonin is an antibacterial agent that exhibits significant activity against methicillin-resistant Staphylococcus aureus (MRSA) and Streptococcus pneumoniae, with a minimum inhibitory concentration (MIC) of 17 μg/mL. It enhances the expression of VEGF-C and VEGF-A mRNA in human microvascular endothelial cells, promotes the interaction of HIF-1α and HIF-1β subunits, and binds to specific DNA sequences associated with HIF. Additionally, Deoxyshikonin demonstrates proangiogenic and antitumor effects by inhibiting colorectal cancer via the PI3K/Akt/mTOR signaling pathway, making it valuable for both antibacterial and cancer research applications. |
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RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
