Product Data Sheet
Polyinosinic-polycytidylic acid
Catalog No. A24651
Polyinosinic-polycytidylic acid (Poly(I:C)) is a synthetic analog of double-stranded RNA that serves as an agonist for toll-like receptor 3 (TLR3) and RIG-I-like receptors, including RIG-I and MDA5. This compound enhances both innate and adaptive immune responses, making it valuable in vaccine development as an adjuvant. Additionally, Poly(I:C) influences the tumor microenvironment and can directly induce apoptosis in cancer cells, highlighting its potential applications in cancer immunotherapy and research.
Chemical Information
| Catalog Num | A24651 |
|---|---|
| M. Wt | 671.406 |
| Formula | (C10H13N4O8P)x.(C9H14N3O8P)x |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 24939-03-5 |
| Synonyms | Poly(I:C) |
| SMILES | O[C@H]1[C@@H](O[C@H](COP(O)(O)=O)[C@H]1O)N2C3=C(C(NC=N3)=O)N=C2.O[C@H]4[C@H](N5C(N=C(N)C=C5)=O)O[C@H](COP(O)(O)=O)[C@H]4O.[x].[x] |
Biological Activity
| Description | Polyinosinic-polycytidylic acid (Poly(I:C)) is a synthetic analog of double-stranded RNA that serves as an agonist for toll-like receptor 3 (TLR3) and RIG-I-like receptors, including RIG-I and MDA5. This compound enhances both innate and adaptive immune responses, making it valuable in vaccine development as an adjuvant. Additionally, Poly(I:C) influences the tumor microenvironment and can directly induce apoptosis in cancer cells, highlighting its potential applications in cancer immunotherapy and research. |
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RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
