Product Data Sheet
GSK215
Catalog No. A24687
GSK215 is a potent and selective PROTAC degrader targeting focal adhesion kinase (FAK) via the VHL E3 ligase. With a pDC50 of 8.4, it induces rapid and sustained degradation of FAK, leading to significant modulation of FAK levels over time. This compound demonstrates an extended pharmacokinetic/pharmacodynamic disconnect, making it a valuable tool for research applications in cancer biology and signaling pathways associated with cell adhesion and migration.
Chemical Information
| Catalog Num | A24687 |
|---|---|
| M. Wt | 985.13 |
| Formula | C50H59F3N10O6S |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 2743427-26-9 |
| Synonyms | |
| SMILES | O=C([C@H]1N(C([C@@H](NC(CN2CCN(C3=CC=C(NC4=NC=C(C(F)(F)F)C(NC5=CC=CC=C5C(NC)=O)=C4)C(OC)=C3)CC2)=O)C(C)(C)C)=O)C[C@H](O)C1)N[C@H](C6=CC=C(C7=C(C)N=CS7)C=C6)C |
Biological Activity
| Description | GSK215 is a potent and selective PROTAC degrader targeting focal adhesion kinase (FAK) via the VHL E3 ligase. With a pDC50 of 8.4, it induces rapid and sustained degradation of FAK, leading to significant modulation of FAK levels over time. This compound demonstrates an extended pharmacokinetic/pharmacodynamic disconnect, making it a valuable tool for research applications in cancer biology and signaling pathways associated with cell adhesion and migration. |
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RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
