Product Data Sheet
JNJ-1013
Catalog No. A24710
JNJ-1013 is a selective degrader of IRAK1, demonstrating potent efficacy with IC50 values of 72 nM for IRAK1, 443 nM for IRAK4, and 1071 nM for VHL. This compound induces apoptosis and promotes the cleavage of PARP, signaling significant pro-apoptotic activity. Additionally, JNJ-1013 effectively reduces the expression of IRAK1, phosphorylated IKBα, and phosphorylated STAT3 (Tyr705), making it a valuable tool for research in inflammatory pathways and therapeutic interventions targeting IRAK1.
Chemical Information
| Catalog Num | A24710 |
|---|---|
| M. Wt | 878.05 |
| Formula | C46H55N9O7S |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 2597343-08-1 |
| Synonyms | JNJ1013 |
| SMILES | COC(C=C1N(CC2)CCC2OCC(N[C@@H](C(C)(C)C)C(N3[C@@H](C[C@H](C3)O)C(N[C@H](C4=CC=C(C5=C(C)N=CS5)C=C4)C)=O)=O)=O)=C(C=C1)NC(C6=CC=CC(C7=CC=NN7)=N6)=O |
Biological Activity
| Description | JNJ-1013 is a selective degrader of IRAK1, demonstrating potent efficacy with IC50 values of 72 nM for IRAK1, 443 nM for IRAK4, and 1071 nM for VHL. This compound induces apoptosis and promotes the cleavage of PARP, signaling significant pro-apoptotic activity. Additionally, JNJ-1013 effectively reduces the expression of IRAK1, phosphorylated IKBα, and phosphorylated STAT3 (Tyr705), making it a valuable tool for research in inflammatory pathways and therapeutic interventions targeting IRAK1. |
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RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
