Product Data Sheet
ARD-266
Catalog No. A24715
ARD-266 is a potent PROTAC degrader targeting the Androgen Receptor (AR) through a von Hippel-Lindau E3 ligase mechanism. It effectively induces AR protein degradation in AR-positive prostate cancer cell lines, including LNCaP, VCaP, and 22Rv1, with DC50 values ranging from 0.2 to 1 nM. Additionally, ARD-266 features an alkyne group that enables copper-catalyzed azide-alkyne cycloaddition (CuAAc) with azide-containing molecules, facilitating versatile applications in chemical biology research.
Chemical Information
| Catalog Num | A24715 |
|---|---|
| M. Wt | 915.51 |
| Formula | C52H59ClN6O7 |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 2666951-70-6 |
| Synonyms | ARD266 |
| SMILES | O=C(C[C@@H](C1=CC=CC=C1)NC([C@H]2N(C([C@H](C(C)C)C3=CC(C)=NO3)=O)C[C@H](O)C2)=O)N(CC4)CCC4C#CC5=CC=C(C(N[C@@H]6C(C)(C)[C@@H](OC7=CC=C(C#N)C(Cl)=C7)C6(C)C)=O)C=C5 |
Biological Activity
| Description | ARD-266 is a potent PROTAC degrader targeting the Androgen Receptor (AR) through a von Hippel-Lindau E3 ligase mechanism. It effectively induces AR protein degradation in AR-positive prostate cancer cell lines, including LNCaP, VCaP, and 22Rv1, with DC50 values ranging from 0.2 to 1 nM. Additionally, ARD-266 features an alkyne group that enables copper-catalyzed azide-alkyne cycloaddition (CuAAc) with azide-containing molecules, facilitating versatile applications in chemical biology research. |
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RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
