Product Data Sheet
DAPI dilactate
Catalog No. A24764
DAPI dilactate is a potent fluorescent dye primarily known for its strong binding affinity to DNA, specifically targeting the AT base pairs in the minor groove of double-stranded DNA. This binding significantly enhances fluorescence intensity, making it a valuable tool for applications in fluorescence microscopy to quantify DNA based on fluorescence signals. While DAPI is effective for staining both live and fixed cells, it does not penetrate intact cell membranes. Additionally, DAPI serves as an inhibitor of acid-sensing ion channel 3 (ASIC3), blocking its function, and is useful in research focused on chronic pain treatments (Ex/Em = 356/451 nm).
Chemical Information
| Catalog Num | A24764 |
|---|---|
| M. Wt | 457.48 |
| Formula | C22H27N5O6 |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 28718-91-4 |
| Synonyms | 4',6-Diamidino-2-phenylindole dilactate |
| SMILES | O=C(C(C)O)O.N=C(C1=CC=C(C2=CC3=CC=C(C(N)=N)C=C3N2)C=C1)N.O=C(C(C)O)O |
Biological Activity
| Description | DAPI dilactate is a potent fluorescent dye primarily known for its strong binding affinity to DNA, specifically targeting the AT base pairs in the minor groove of double-stranded DNA. This binding significantly enhances fluorescence intensity, making it a valuable tool for applications in fluorescence microscopy to quantify DNA based on fluorescence signals. While DAPI is effective for staining both live and fixed cells, it does not penetrate intact cell membranes. Additionally, DAPI serves as an inhibitor of acid-sensing ion channel 3 (ASIC3), blocking its function, and is useful in research focused on chronic pain treatments (Ex/Em = 356/451 nm). |
|---|
RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
