Product Data Sheet
GLPG3312
Catalog No. A25045
GLPG3312 is a potent SIK inhibitor, demonstrating IC50 values of 2.0 nM, 0.7 nM, and 0.6 nM for SIK1, SIK2, and SIK3, respectively. It exhibits significant anti-inflammatory and immunomodulatory activities both in vitro on human primary myeloid cells and in vivo in mouse models. Due to its favorable oral bioavailability, GLPG3312 is an important reagent for research into various inflammatory and immune-related diseases.
Chemical Information
| Catalog Num | A25045 |
|---|---|
| M. Wt | 453.44 |
| Formula | C23H21F2N5O3 |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 2340388-72-7 |
| Synonyms | |
| SMILES | O=C(NC1CC1)C2=C(OC)C=C(N3C=NC4=CC(C5=CN(C)N=C5)=CC=C34)C=C2OC(F)F |
Biological Activity
| Description | GLPG3312 is a potent SIK inhibitor, demonstrating IC50 values of 2.0 nM, 0.7 nM, and 0.6 nM for SIK1, SIK2, and SIK3, respectively. It exhibits significant anti-inflammatory and immunomodulatory activities both in vitro on human primary myeloid cells and in vivo in mouse models. Due to its favorable oral bioavailability, GLPG3312 is an important reagent for research into various inflammatory and immune-related diseases. |
|---|
RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
